{"id":661,"date":"2014-05-21T05:16:50","date_gmt":"2014-05-21T05:16:50","guid":{"rendered":"http:\/\/protasis.net\/blog2014\/?page_id=661"},"modified":"2014-06-28T07:07:33","modified_gmt":"2014-06-28T07:07:33","slug":"validation","status":"publish","type":"page","link":"http:\/\/protasis.net\/blog2014\/?page_id=661","title":{"rendered":"System Validation"},"content":{"rendered":"<section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><h2>Performance Certification<\/h2>\n<p><span style=\"font-family: Arial;\">Trust in Protasis to provide <i><b>affordable sensitivity<\/b><\/i>\u00a0to your facility.\u00a0 Miniaturization gives you the highest NMR mass sensitivity attainable at the lowest sample utilization and reagent consumption.\u00a0 To that we can add efficient sample management to <i><b>boost productivity<\/b><\/i> in your lab beyond anything you&#8217;ve ever seen.\u00a0 You can process thousands of samples per month with genuine high throughput NMR analysis. <span style=\"font-size: 9pt;\">We&#8217;ll prepare in our factory by assembling probes and supporting software, fluidics and robotics into integrated platforms and certifying their performance.\u00a0 Then we&#8217;ll work with you at your location to install the equipment and train you on <i><b>how to use it effectively<\/b><\/i> to achieve full perfrormance every day.\u00a0 <\/span><span style=\"font-family: Arial;\">We&#8217;ll <\/span><span style=\"font-family: Tahoma;\"> <span style=\"font-family: Arial;\"> <a style=\"color: #0000aa; text-decoration: none; font-family: Tahoma, Verdana; font-size: 11px;\" href=\"http:\/\/www.protasis.com\/MicroFlowNMR\/certificate-blank.htm\" target=\"main\">recertify<\/a><\/span><\/span><span style=\"font-size: 9pt;\"> performance during the installation and provide you with the numbers that demonstrate that MicroFlow NMR is working at its <i><b>top performance level<\/b><\/i> with your magnet and your spectrometer.\u00a0 We&#8217;ll work closely with you to plan the installation with our <i><b>site preparation checklist<\/b><\/i>.\u00a0 Our products systems are flexible so that we can be responsive to your workflow, needs and concerns about locating One-Minute NMR equipment. Performance at this level presents special challenges.\u00a0 These probes are so sensitive they will easily uncover existing inhomogeneities or vibrations in your NMR configuration.\u00a0 Straightforward steps can generally resolve minor problems.\u00a0 We&#8217;ll work with you to optimize your <i><b>total system performance<\/b><\/i>.<\/span><\/span><\/p>\n<p><span style=\"font-size: 9pt; font-family: Arial;\">Orders come backed with <strong> <i>100% Performance Certification<\/i><span style=\"color: #3333ff;\">.<\/span>\u00a0 <\/strong>We&#8217;ll stick with you, whatever it takes to meet sensitivity specifications and get everything working together.<\/span><\/p>\n<p><span style=\"font-size: 9pt; font-family: Arial;\">Let your mind rest easy. It\u2019s part of <i><b>our commitment to you<\/b><\/i> as a valued customer.\u00a0 If you are having any problems with your system after the installation, submit a support request through the support center for a prompt response and resolution to your problem. <\/span><\/p>\n<\/div><\/section>\n\t<div  class='av_promobox avia-button-yes '>\t\t<div class='avia-promocontent'><p>\n<span style=\"font-family: Arial,Helvetica,sans-serif; font-size: small;\"><span style=\"font-size: small;\"><span style=\"font-family: Arial,Helvetica,sans-serif;\">For concerns about products or services, call or submit a support request through the <a style=\"color: #0000aa; text-decoration: none; font-family: Tahoma, Verdana; font-size: 11px;\" href=\"http:\/\/www.protasis.com\/support\/index.php\">support center<\/a> for a prompt response and speedy resolution to your problem. <\/span><\/span><\/span><\/p>\n<\/div><div class='avia-button-wrap avia-button-right '><a href='' class='avia-button  avia-icon_select-yes-left-icon avia-color-theme-color avia-size-large avia-position-right '  target=\"_blank\"   ><span class='avia_button_icon avia_button_icon_left ' aria-hidden='true' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Help Desk<\/span><\/a><\/div>\t<\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section alternate_color avia-section-default avia-no-shadow avia-bg-style-scroll  container_wrap sidebar_right'   ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-661'><div class='entry-content-wrapper clearfix'>\n<section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><h2>References<\/h2>\n<\/div><\/section>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_right'   ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-661'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_third  flex_column_div first  \" ><section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><p>&#8220;Quantitative NMR is relatively rapid and easy to implement for analysis (e.g., mixtures, metabolomics, pharmaceutical preparations, and natural products) because of the specific advantages it offers, namely:<\/p>\n<ol>\n<li>determination of molecular structure (i.e. verification of the authenticity by direct structural evidence);<\/li>\n<li>short measuring time;<\/li>\n<li>non-destructive nature, so that samples can be used for other analysis;<\/li>\n<li>no necessity for isolation and purification of analyte from its mixture (i.e. easy sample-preparation steps);<\/li>\n<li>quantitation of multiple components using single reference compounds (i.e. no specific reference required);<\/li>\n<li>ratio-determination step that does not need any intensity calibration; and,<\/li>\n<li>better accuracy and precision. Method-validation parameters (e.g., precision, accuracy, linearity, and reproducibility) qualify NMR as a quantitative analytical technique.&#8221;<\/li>\n<\/ol>\n<p><strong>Quantitative 1H NMR spectroscopy<\/strong>, <em>Santosh Kumar Bharti, Raja Roy<\/em>, Trends in Analytical Chemistry, Vol. 35, 2012<\/p>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div   \" ><section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><p>&#8220;The qNMR method employed herein proved to be rapid as well as easy to implement. The different aspects of performance of the method, such as linearity, precision and accuracy, satisfied our requirements well. It offers an excellent choice over previously described procedures and can be used for routine quality control and stability analysis of Pioglitazone<br \/>\nhydrochloride in solid dosage forms. Assay results obtained by qNMR were confirmed by comparing with in-house HPLC method. Furthermore, any modern NMR equipment\u00a0 operating at a field of 300MHz or more may be used, assuming that suitable processing of data is performed.<\/p>\n<p>qNMR has a high potential in analysis of pharmaceutical products due to the simplicity,<br \/>\nreliability, simultaneous identification and quantification, and the fact that no reference<br \/>\ncompound of drug is needed.&#8221;<\/p>\n<p><strong>Quantitative determination and Validation of Pioglitazone in Pharmaceutical<\/strong><br \/>\n<strong> using Quantitative Nuclear Magnetic Resonance Spectroscopy<\/strong><br \/>\n<em>H. H. Gadape and K. S. Parikh*<\/em><br \/>\nDepartment of Chemistry, Sheth M. N. Science College, Rajmahal Road, Patan, North Gujarat, INDIA<\/p>\n<p>J. Chem. Pharm. Res., 2011, 3(1):649-664<\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":253,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/661"}],"collection":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=661"}],"version-history":[{"count":15,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/661\/revisions"}],"predecessor-version":[{"id":664,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/661\/revisions\/664"}],"up":[{"embeddable":true,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/253"}],"wp:attachment":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}