{"id":143,"date":"2014-05-09T22:54:14","date_gmt":"2014-05-09T22:54:14","guid":{"rendered":"http:\/\/protasis.net\/blog2014\/?page_id=143"},"modified":"2014-07-22T01:21:12","modified_gmt":"2014-07-22T01:21:12","slug":"process-analytics","status":"publish","type":"page","link":"http:\/\/protasis.net\/blog2014\/?page_id=143","title":{"rendered":"Reaction Monitoring"},"content":{"rendered":"<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='full_slider_1' class='avia-fullwidth-slider main_color avia-shadow  container_wrap sidebar_right'   ><div  data-size='featured'  data-lightbox_size='large'  data-animation='slide'  data-ids='1500,1508'  data-video_counter='0'  data-autoplay='true'  data-bg_slider='false'  data-slide_height=''  data-handle='av_slideshow_full'  data-interval='15'  data-class=' '  data-css_id=''  data-scroll_down=''  data-control_layout='av-control-default'  data-custom_markup=''  data-perma_caption=''  data-autoplay_stopper=''  data-src=''  data-position='top left'  data-repeat='no-repeat'  data-attach='scroll'  data-stretch=''  data-default-height='28.666666666667'  class='avia-slideshow avia-slideshow-1  av-control-default av-default-height-applied avia-slideshow-featured av_slideshow_full   avia-slide-slider '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><ul class='avia-slideshow-inner' style='padding-bottom: 9.2951991828396%;'><li  class=' slide-1 ' ><div data-rel='slideshow-1' class='avia-slide-wrap'  ><div class = \"caption_fullwidth av-slideshow-caption caption_center\"><div class = \"container caption_container\"><div class = \"slideshow_caption\"><div class = \"slideshow_inner_caption\"><div class = \"slideshow_align_caption\"><h2  class='avia-caption-title'  itemprop=\"name\" >Monitor Reactants &amp; Products<\/h2><div class='avia-caption-content '  itemprop=\"description\"  ><p>See it all with universal, quantitative Process NMR!<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img src='http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/Miastra_-_panarama-980Wx90H.jpg' width='979' height='91' title='Miastra_-_panarama-980Wx90H' alt=''  itemprop=\"contentURL\"  \/><\/div><\/li><li  class=' slide-2 ' ><div data-rel='slideshow-1' class='avia-slide-wrap'  ><div class = \"caption_fullwidth av-slideshow-caption caption_center\"><div class = \"container caption_container\"><div class = \"slideshow_caption\"><div class = \"slideshow_inner_caption\"><div class = \"slideshow_align_caption\"><h2  class='avia-caption-title'  itemprop=\"name\" >Enable Accurate Kinetic Studies<\/h2><div class='avia-caption-content '  itemprop=\"description\"  ><p>Get the data you need to scale up your process!<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img src='http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/Slievenamon_2006-07-01-980Wx90H1.jpg' width='986' height='90' title='Slievenamon_2006-07-01-980Wx90H' alt=''  itemprop=\"contentURL\"  \/><\/div><\/li><\/ul><div class='avia-slideshow-arrows avia-slideshow-controls'><a href='#prev' class='prev-slide' aria-hidden='true' data-av_icon='\ue87c' data-av_iconfont='entypo-fontello'>Previous<\/a><a href='#next' class='next-slide' aria-hidden='true' data-av_icon='\ue87d' data-av_iconfont='entypo-fontello'>Next<\/a><\/div><div class='avia-slideshow-dots avia-slideshow-controls'><a href='#1' class='goto-slide active' >1<\/a><a href='#2' class='goto-slide ' >2<\/a><\/div><\/div><\/div>\n<div class=\"flex_column av_two_third  flex_column_div first  \" ><div style='padding-bottom:10px;' class='av-special-heading av-special-heading-h2    '><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >Reaction Monitoring<\/h2><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div>\n<section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><p>Process chemists provide critical support to connect laboratory researh to scaled-up manufacturable reactions.\u00a0 There job includes evaluating reactions at different temperatures, in different solvents and with different catalysts, often with the goal of maximizing yield while minimizing by-products.\u00a0 NMR is uniquely non-desctructive and universal allowing real-time monitoring of all hydrocarbon species simultanously without special calibration.\u00a0 Proton NMR offers superior speed, accuracy flexibility and flowthru robustness.<\/p>\n<p>Protasis system solutions can enhance the efficiency and quality of most biopharmaceutical processes.<\/p>\n<p>Key applications include:<a href=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\"alignright wp-image-1334 size-medium\" src=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-200x300.jpg\" alt=\"Reactor\" width=\"200\" height=\"300\" srcset=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-200x300.jpg 200w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-686x1030.jpg 686w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-600x900.jpg 600w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-1000x1500.jpg 1000w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-470x705.jpg 470w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor-450x675.jpg 450w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/06\/Reactor.jpg 1024w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<ul>\n<li>structure confirmation of all active ingredients<\/li>\n<li>tracking of reagent depletion over course of reaction<\/li>\n<li>tracking of byproducts generated during reaction<\/li>\n<li>linear quantitation of all protonated species during reaction<\/li>\n<li>rapid flagging and identification of contaminents at any time<\/li>\n<li>monitoring of the effects of process or manufacturing changes<\/li>\n<li>troubleshooting product support applications.<\/li>\n<\/ul>\n<p>CryoFree HTS magnets allow 200MHz (15&#8243;) or 400MHz (24&#8243;)\u00a0 NMR to be used in process labs and moved when needed.<\/p>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div   \" ><section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><h3>More Information<\/h3>\n<p><strong>Reaction Monitoring Downloads<\/strong><\/p>\n<div class='w3eden'>\n                 <div class=\"navbar navbar-default\" role=\"navigation\">\n  <div class=\"container-fluid\">\n    <!-- Brand and toggle get grouped for better mobile display -->\n    <div class=\"navbar-header\">\n      <button type=\"button\" class=\"navbar-toggle\" data-toggle=\"collapse\" 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style='clear:both'><\/div><div class='text-center'><ul  class=\"pagination pagination-centered\"><\/ul><\/div>\n<div style='clear:both'><\/div><div style='clear:both'><\/div><\/div>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_two_third  flex_column_div first  \" ><section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><h3>Featured Video<\/h3>\n<p><strong>Stirred Tank Reactor in 3D, by Andriy Sokolov<\/strong><\/p>\n<\/div><\/section><br \/>\n<div  class='avia-video avia-video-4-3  '  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\" ><div class='avia-iframe-wrap'><iframe width=\"1333\" height=\"1000\" src=\"https:\/\/www.youtube.com\/embed\/FM0DScymjKc?feature=oembed\" frameborder=\"0\" allowfullscreen><\/iframe><\/div><\/div><\/p><\/div>\n<div class=\"flex_column av_one_third  flex_column_div   \" ><section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><h3>Our Partners<\/h3>\n<p><strong>Reactor Modeling<\/strong><\/p>\n<\/div><\/section><br \/>\n<div  data-autoplay='false'  data-interval='5'  data-animation='slide'  class='avia-logo-element-container av-border-deactivate avia-logo-slider avia-content-slider avia-smallarrow-slider avia-content-slider-active noHover avia-content-slider1 avia-content-slider-odd ' ><div class='avia-smallarrow-slider-heading  no-logo-slider-navigation  no-logo-slider-heading '><\/div><div class='avia-content-slider-inner'><div class='slide-entry-wrap'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div  class='slide-entry flex_column no_margin post-entry slide-entry-overview slide-loop-1 slide-parity-odd  post-entry-last  av_fullwidth first real-thumbnail'><img  itemprop=\"contentURL\"  width=\"1026\" height=\"480\" src=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/fluent.jpg\" class=\"attachment-no scaling size-no scaling\" alt=\"\" decoding=\"async\" loading=\"lazy\" srcset=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/fluent.jpg 1026w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/fluent-300x140.jpg 300w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/fluent-600x280.jpg 600w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/fluent-705x329.jpg 705w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/fluent-450x210.jpg 450w\" sizes=\"(max-width: 1026px) 100vw, 1026px\" \/><\/div><\/div><\/div><\/div><\/p><\/div>\n\t<div  class='av_promobox avia-button-yes '>\t\t<div class='avia-promocontent'><\/p>\n<h2 style=\"text-align: center;\">Optimize your process with Veritas NMR.<\/h2>\n<p style=\"text-align: center;\"><strong>Generate Certificates of Performance with Protasis Qomply software.<\/strong><\/p>\n<p>\n<\/div><div class='avia-button-wrap avia-button-right '><a href='http:\/\/www.protasis.net\/catalog\/index.php?route=product\/category&amp;path=200_201' class='avia-button  avia-icon_select-yes-left-icon avia-color-theme-color avia-size-large avia-position-right '  target=\"_blank\"   ><span class='avia_button_icon avia_button_icon_left ' aria-hidden='true' data-av_icon='\ue8ad' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Learn More<\/span><\/a><\/div>\t<\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section alternate_color avia-section-default avia-no-shadow avia-bg-style-scroll  container_wrap sidebar_right'   ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-143'><div class='entry-content-wrapper clearfix'>\n<section class=\"av_textblock_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '   itemprop=\"text\" ><h3>Reaction Monitoring with qNMR<\/h3>\n<p><strong>See all the details of your reaction over time!<\/strong><\/p>\n<\/div><\/section>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_right'   ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-143'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_two_third  flex_column_div first  \" ><div class='template-blog '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Blog\" ><article class='post-entry post-entry-type-standard post-entry-843 post-loop-1 post-parity-odd post-entry-last single-small with-slider post-843 post type-post status-publish format-standard has-post-thumbnail hentry category-applications category-reactor-monitoring'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" ><div class='blog-meta'><a href='http:\/\/protasis.net\/blog2014\/?p=843' class='small-preview' title='Pfizer-Protasis SciEx2013 Talk'><img width=\"180\" height=\"180\" src=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-180x180.jpg\" class=\"attachment-square size-square wp-post-image\" alt=\"\" decoding=\"async\" loading=\"lazy\" srcset=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-180x180.jpg 180w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-80x80.jpg 80w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-36x36.jpg 36w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-120x120.jpg 120w, http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-450x450.jpg 450w\" sizes=\"(max-width: 180px) 100vw, 180px\" \/><span class=\"iconfont\" aria-hidden='true' data-av_icon='\ue836' data-av_iconfont='entypo-fontello'><\/span><\/a><\/div><div class='entry-content-wrapper clearfix standard-content'><header class=\"entry-content-header\"><h2 class='post-title entry-title'  itemprop=\"headline\" >\t<a href='http:\/\/protasis.net\/blog2014\/?p=843' rel='bookmark' title='Permanent Link: Pfizer-Protasis SciEx2013 Talk'>Pfizer-Protasis SciEx2013 Talk\t\t\t<span class='post-format-icon minor-meta'><\/span>\t<\/a><\/h2><span class='post-meta-infos'><time class='date-container minor-meta updated' >May 26, 2014<\/time><span class='text-sep text-sep-date'>\/<\/span><span class='comment-container minor-meta'><a href=\"http:\/\/protasis.net\/blog2014\/?p=843#respond\" class=\"comments-link\" >0 Comments<\/a><\/span><span class='text-sep text-sep-comment'>\/<\/span><span class=\"blog-categories minor-meta\">in <a href=\"http:\/\/protasis.net\/blog2014\/?cat=6\" rel=\"tag\">Applications<\/a>, <a href=\"http:\/\/protasis.net\/blog2014\/?cat=23\" rel=\"tag\">Reactor Monitoring<\/a> <\/span><span class=\"text-sep text-sep-cat\">\/<\/span><span class=\"blog-author minor-meta\">by <span class=\"entry-author-link\" ><span class=\"vcard author\"><span class=\"fn\"><a href=\"http:\/\/protasis.net\/blog2014\/?author=2\" title=\"Posts by David Strand\" rel=\"author\">David Strand<\/a><\/span><\/span><\/span><\/span><\/span><\/header><div class=\"entry-content\"  itemprop=\"text\" ><p>Show key slides from SciEx2013 talk by David Foley.<\/p>\n<p><a href=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-844 size-portfolio\" src=\"http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-495x400.jpg\" alt=\"IMG_0724\" width=\"495\" height=\"400\" \/><\/a><\/p>\n<\/div><footer class=\"entry-footer\"><\/footer><div class='post_delimiter'><\/div><\/div><div class='post_author_timeline'><\/div><span class='hidden'>\n\t\t\t<span class='av-structured-data'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  itemprop='image'>\n\t\t\t\t\t   <span itemprop='url' >http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/IMG_0724-e1401089218731.jpg<\/span>\n\t\t\t\t\t   <span itemprop='height' >480<\/span>\n\t\t\t\t\t   <span itemprop='width' >640<\/span>\n\t\t\t\t  <\/span><span class='av-structured-data'  itemprop=\"publisher\" itemtype=\"https:\/\/schema.org\/Organization\" itemscope=\"itemscope\" >\n\t\t\t\t<span itemprop='name'>David Strand<\/span>\n\t\t\t\t<span itemprop='logo' itemscope itemtype='http:\/\/schema.org\/ImageObject'>\n\t\t\t\t   <span itemprop='url'>http:\/\/protasis.net\/blog2014\/wp-content\/uploads\/2014\/05\/Protasis-MRM-LOGO2-300x128.png<\/span>\n\t\t\t\t <\/span>\n\t\t\t  <\/span><span class='av-structured-data'  itemprop=\"author\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Person\" ><span itemprop='name'>David Strand<\/span><\/span><span class='av-structured-data'  itemprop=\"datePublished\" datetime=\"2014-05-26T07:28:08+00:00\" >2014-05-26 07:28:08<\/span><span class='av-structured-data'  itemprop=\"dateModified\" itemtype=\"https:\/\/schema.org\/dateModified\" >2014-07-05 19:45:34<\/span><span class='av-structured-data'  itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/mainEntityOfPage\" ><span itemprop='name'>Pfizer-Protasis SciEx2013 Talk<\/span><\/span><\/span><\/article><\/div><\/div>\n<div class=\"flex_column av_one_third  flex_column_div   \" ><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":294,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/143"}],"collection":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=143"}],"version-history":[{"count":52,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/143\/revisions"}],"predecessor-version":[{"id":2098,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/143\/revisions\/2098"}],"up":[{"embeddable":true,"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=\/wp\/v2\/pages\/294"}],"wp:attachment":[{"href":"http:\/\/protasis.net\/blog2014\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}